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[Immunopathogenesis of psoriasis and its current therapy ]
1Katedra farmaceutické technologie Farmaceutické fakulty Univerzity Karlovy, Hradec Králové. svozil@faf.cuni.cz
Summary
Psoriasis is an inflammatory skin disease with complex origins, involving immune system interactions. Current treatments manage symptoms by targeting these pathogenetic processes, but no permanent cure exists.
Area of Science:
- Dermatology
- Immunology
- Biochemistry
Context:
- Psoriasis is a chronic inflammatory skin condition characterized by hyperproliferation.
- The precise etiology remains unclear, but significant immunological, bioregulatory, and biochemical alterations are recognized.
Purpose:
- To review the known immunological, bioregulatory, and biochemical changes associated with psoriasis.
- To discuss the mechanisms of action for various antipsoriatic treatments.
Summary:
- Psoriasis involves a complex network of immune cells and factors within the affected skin.
- Antipsoriatic therapies target this network at various levels, employing both external and internal methods.
- Classical treatments include UV radiation (SUP), psoralens (PUVA), tar, and dithranol, alongside topical agents like corticoids, vitamin D derivatives, salicylic acid, urea, and tar.
Impact:
- Current therapeutic strategies aim to manage psoriasis symptoms by intervening in pathogenetic pathways.
- No known treatment offers a permanent elimination of psoriasis, necessitating combination therapies.