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Fever and neutrophilic alveolitis caused by a vanadium based catalyst
O Vandenplas1, F Binard-Van Cangh, J Gregoire
1Service de Pneumologie, Cliniques Universitaires de Mont-Godinne, Université Catholique de Louvain, Yvoir, Belgium Fonds des Maladies Professionnelles, Brussels, Belgium. oliver.vandenplas@pneu.ucl.ac.be
Aims:
To investigate a worker who experienced systemic and respiratory symptoms when exposed to a vanadium containing powder used as a catalyst in the production of maleic anhydride.
Methods:
The investigation included inhalation challenge with the suspected compound combined with monitoring of lung function tests and post-challenge bronchoalveolar lavage.
Results:
Exposure to the vanadium containing catalyst for 120 minutes resulted in a sustained decline in forced vital capacity and forced expiratory volume in one second, while the transfer factor for carbon monoxide did not change significantly. The subject developed fever and peripheral blood neutrophilia. Bronchoalveolar lavage performed 48 hours after the end of challenge exposure showed a marked increase in neutrophils (60% of total cell count).
Conclusions:
Exposure to vanadium can cause a metal fume fever-like syndrome associated with neutrophilic alveolitis.