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Correlation of biochemical parameters with single parathyroid adenoma weight and volume
Vinita Bindlish1, Jeremy L Freeman, Ian J Witterick
1Department of Otolaryngology, Mount Sinai Hospital, University of Toronto, 401-600 University Avenue, Toronto, Ontario, Canada, M5G 1X5.
Objective:
To determine the relationship of the biochemical parameters serum phosphate, serum calcium, and serum parathyroid hormone levels with respect to parathyroid adenoma weight and volume in primary hyperparathyroidism.
Study Design:
Retrospective review of 63 cases of primary hyperparathyroidism from 1992 to 1998.
Methods:
Single parathyroid adenomas were identified from surgical pathology reports. Preoperative calcium, phosphate, and parathyroid hormone levels were collected from charts. The volume of the adenoma was calculated using a mathematical equation for the volume of an ellipsoid object. The data were analyzed using a multiple analysis of variance, and a correlation coefficient was calculated. The level of significance was set at p < or = .05.
Results:
With respect to adenoma volume, there was a significant correlation with serum calcium and parathormone levels (p = .0001 and p = .0001, respectively). There was no significant correlation between serum phosphate and adenoma volume. With respect to adenoma weight, there was a significant correlation with serum calcium and parathormone levels (p = .0001 and p = .0001, respectively). There was no significant correlation between serum phosphate and adenoma weight.
Conclusions:
Preoperative serum calcium and parathormone levels may be able to predict adenoma weight and volume in primary hyperparathyroidism for a single adenoma.