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[Central nervous system germinoma: retrospective study of six cases]
H Sifat1, K Haddadi, E el Ghazi
1Service de radiothérapie, Institut national d'oncologie, BP 6213 RI-Rabat, Maroc.
Purpose:
Retrospective analysis of six patients with intracranial germinoma treated in INO and a literature review.
Materials And Methods:
Six patients were treated from 1993 to 1998, for histologically verified primary intracranial germinoma. Median age was 18 years (range: 14-26 years). All patients received chemo-radiotherapy (4FP + radiotherapy from 30 to 50 Gy).
Results:
4 tumours were in complete remission. Two patients have kept non-evolutive residual cyst. Five patients are alive with non-evolutive disease after 15-40 months of follow-up (average: 27 months). One patient was lost to follow-up, 14 months after treatment, without disease.
Conclusion:
The treatment of intracranial germinoma is currently first line chemotherapy followed by low-dose and limited irradiation.