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Cephalosporin-resistant pneumococcal pneumonia: does it, affect outcome?
R K Ailani1, A Alimchandani, J Hidalgo
1Department of Internal Medicine, Henry Ford Hospital, Detroit, Michigan 48202, USA.
Respiratory Medicine
|November 5, 2002
Summary
High-level cephalosporin resistance in Streptococcus pneumoniae pneumonia prolongs treatment response and hospital stay. This finding highlights the clinical significance of cephalosporin resistance in pneumococcal pneumonia outcomes.
Area of Science:
- Infectious Diseases
- Antimicrobial Resistance
- Pulmonary Medicine
Background:
- Penicillin resistance in Streptococcus pneumoniae pneumonia has not significantly impacted patient outcomes.
- The clinical significance of cephalosporin resistance in Streptococcus pneumoniae pneumonia remains understudied.
Purpose of the Study:
- To investigate the impact of high-level cephalosporin resistance in Streptococcus pneumoniae pneumonia (H-CRSPP) on patient outcomes.
- To compare outcomes between patients with H-CRSPP and those with cephalosporin-sensitive pneumococcal pneumonia.
Main Methods:
- Retrospective matched case-control study conducted at two academic hospitals.
- Twenty-six patients with H-CRSPP were matched with controls based on pneumonia severity index (PSI) and other factors.
- Outcomes assessed included mortality, length of hospital stay, and time to treatment response.
Main Results:
- Patients with H-CRSPP experienced a significantly longer time to treatment response (6.5 days vs. 4.1 days, P=0.05).
- H-CRSPP was associated with a longer length of hospital stay (15.4 days vs. 9.2 days, P=0.02).
- No significant differences were observed in mortality or other assessed outcomes between the groups.
Conclusions:
- Cephalosporin resistance in Streptococcus pneumoniae pneumonia significantly impacts the clinical course of the disease.
- The findings underscore the importance of considering cephalosporin resistance when managing pneumococcal pneumonia.