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Induction of homosynaptic long-term depression in entorhinal cortex
Mi Young Cheong1, Sung Hwan Yun, Inhee Mook-Jung
1Institute for Medical Sciences, Ajou University School of Medicine, Suwon 442-721, South Korea.
Brain Research
|November 5, 2002
Abstract:
Prolonged low frequency stimulation (1 Hz, 15 min) induced significant long-term depression (LTD) in hippocampal CA1 region and superficial, but not deep, layers of rat medial entorhinal cortex (EC) in vitro. In the presence of D-AP5, significant LTD was induced in EC superficial layers, but not in CA1 or EC deep layers. These results show differences in characteristics of LTD induction across CA1, EC superficial layers, and EC deep layers.