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Related Experiment Video

Updated: Jul 9, 2026

Habituation and Prepulse Inhibition of Acoustic Startle in Rodents

Habituation and Prepulse Inhibition of Acoustic Startle in Rodents

Published on: September 1, 2011

Compulsions, Parkinson's disease, and stimulation.

Luc Mallet¹, Valérie Mesnage, Jean-Luc Houeto

¹CNRS UMR 7593 and Service de Psychiatrie, Pavillon Clérambault, GH Pitié-Salpêtrière, Hôpital de la Salpêtrière, Assistance Publique-Hôpital de Paris, 75651 Cedex 13, Paris, France. lucmallet@free.fr

Lancet (London, England)

|November 5, 2002

Summary

Subthalamic nucleus stimulation for Parkinson's disease also improved severe obsessive-compulsive disorder (OCD) symptoms in two patients. This suggests high-frequency stimulation may benefit OCD by modulating subcortical-limbic circuits.

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Area of Science:

Neuroscience
Neurology
Psychiatry

Background:

Obsessive-compulsive disorder (OCD) is hypothesized to involve dysfunctions in cortico-striato-pallido-thalamo-cortical (CSPTC) circuits.
Deep brain stimulation (DBS) is a therapeutic option for movement disorders and some psychiatric conditions.

Observation:

Two patients with Parkinson's disease and severe OCD underwent subthalamic nucleus (STN) electrode implantation for parkinsonian symptoms.
Postoperatively, both patients experienced significant improvement in parkinsonian disability.

Findings:

Within two weeks, OCD symptoms markedly improved, with reported reductions of 58% and 64% on the Yale-Brown Obsessive Compulsive Scale for the two patients.
Obsessions and compulsions were significantly reduced following STN DBS.

Implications:

High-frequency stimulation of the subthalamic nucleus may offer a novel therapeutic approach for severe OCD.
This suggests that STN DBS can modulate subcortical-limbic circuitry implicated in OCD pathophysiology.
Further research into DBS for treatment-refractory OCD is warranted.