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Related Experiment Videos

Brain activation during smooth-pursuit eye movements.

Jody Tanabe1, Jason Tregellas, David Miller

  • 1Department of Radiology, University of Colorado Health Sciences Center, Denver, 80262, USA.

Neuroimage
|November 5, 2002
PubMed
Summary

Functional MRI (fMRI) reliably detects brain activity during smooth-pursuit eye movements in dorsal cortical eye fields and cerebellum. This study validates fMRI for studying eye movement disorders in patients.

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Area of Science:

  • Neuroscience
  • Cognitive Neuroscience
  • Neuroimaging

Background:

  • Functional magnetic resonance imaging (fMRI) shows promise for studying eye movement disorders.
  • Previous fMRI studies on smooth-pursuit eye movements used limited subjects and fixed-effects analyses.
  • The reliability of fMRI in identifying brain regions involved in normal eye movements requires further investigation.

Purpose of the Study:

  • To establish the reliability of brain region activation during smooth-pursuit eye movements using fMRI in healthy subjects.
  • To account for intersubject variability through random-effects analysis in whole-brain imaging.
  • To identify brain areas sensitive to attentional modulation during eye movements.

Main Methods:

  • Whole-brain fMRI imaging at 1.5 Tesla.

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  • Utilized random-effects analysis to account for intersubject variation.
  • Elicited smooth-pursuit eye movements in participants.

    • Main Results:

    • Consistent activation was observed in dorsal cortical eye fields and the cerebellum during smooth-pursuit eye movements.
    • Subcortical activation was significantly reduced but not eliminated by random-effects analysis.
    • Session-dependent changes in activation suggest attentional modulation in areas like the supplementary eye fields.

    Conclusions:

    • fMRI, particularly with random-effects analysis, reliably detects activation in key brain regions during smooth-pursuit eye movements.
    • The findings support the use of fMRI for investigating eye movement dysfunctions in patient populations.
    • Specific brain regions, such as supplementary eye fields, may be sensitive to attention during eye movements.