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Related Experiment Videos

CD8 T cell responses to infectious pathogens.

Phillip Wong1, Eric G Pamer

  • 1Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA. wongp@mskcc.org

Annual Review of Immunology
|November 5, 2002
PubMed
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CD8 T cells are crucial for fighting infections, with new research revealing their high frequency and programmed expansion in tissues. Understanding these immune responses aids in developing better treatments for various infections.

Area of Science:

  • Immunology
  • Infectious Diseases
  • Cellular Biology

Background:

  • CD8 T cells are vital for adaptive immunity against viral, bacterial, and protozoal pathogens.
  • Recent advancements in quantification and characterization techniques have significantly improved our understanding of T cell responses in vivo.
  • Previously underestimated, pathogen-specific CD8 T cells are now recognized to exist at high frequencies, especially in non-lymphoid tissues.

Purpose of the Study:

  • To review recent progress in understanding CD8 T cell-mediated immunity across different infectious agents.
  • To highlight the programmed nature of T cell expansion, largely independent of antigen load.
  • To explore the interplay between innate inflammatory responses and adaptive CD8 T cell kinetics and magnitude.

Main Methods:

Related Experiment Videos

  • Focus on major murine models of CD8 T cell-mediated immunity.
  • Utilizes new methods for accurate quantification and characterization of pathogen-specific CD8 T cells.
  • Reviews and synthesizes recent findings on T cell responses to viral, bacterial, and protozoal infections.

Main Results:

  • CD8 T cell responses are more frequent and widespread in tissues than previously thought.
  • T cell expansion during infection is a programmed process, not solely driven by antigen concentration.
  • Innate inflammatory signals critically influence the dynamics and characteristics of long-term CD8 T cell immunity.

Conclusions:

  • CD8 T cell immunity is a complex, programmed response influenced by pathogen type and innate immunity.
  • Further research in murine models provides valuable insights into human immune responses to infection.
  • Advanced techniques are revolutionizing the study of cellular immunity in infectious diseases.