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7-Methoxy-1H-indazole, a new inhibitor of neuronal nitric oxide synthase
Jana Sopková-de Oliveira Santos1, Valérie Collot, Sylvain Rault
1Centre d'Etudes et de Recherche sur le Médicament de Normandie (CERMN), Université de Caen, 5 Rue Vaubénard, 14032 Caen, France. sopkova@pharmacie.unicaen.fr
Acta Crystallographica. Section C, Crystal Structure Communications
|November 5, 2002
Abstract:
The crystal structure of 7-methoxy-1H-indazole, C(8)H(8)N(2)O, an inhibitor of nitric oxide synthase, shows that the methoxy group lies in the plane of the indazole system with its methyl group located trans to the indazole N-H group. The crystal packing consists principally of hydrogen-bonded trimers. Intermolecular hydrogen-bonding interactions are formed between the indazole N atoms, with the N-H group as a hydrogen-bond donor and the remaining N atom as an acceptor.