[Humoral immunity in mice with transplantable leukemia during chemoimmunotherapy]

The article treats of the effect of cyclophosphamide (CP), and complete Freund's adjuvant (CFA) and their combination on the development of transplantable leukemia-hemocytoblastosis in mice and some host humoral immune reactions. The optimal combinations of the CP (on the 3rd day after the transplantation of leukemia) and of the CFA (on the 10th day) led to increase in the average survival up to 93,9 days (8.5 days in control). This combination also increased the survival of 42.9% of the animals for over 180 days. Enhancement of humoral immunity proved to take place in the course of chemoimmunotherapy. In spite of deep immunodepression after the CP and CFA administration the number of antibody-producing cells increased and enhancement of the cytotoxic activity of the serum IgM was observed.