[Common variable immunodeficiency concomitant with liver cirrhosis--case report]
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Induction of Drug-Induced, Autoimmune Hepatitis in BALB/c Mice for the Study of Its Pathogenic Mechanisms
Published on: May 29, 2020
Anna Macura-Biegun1, Danuta Kowalczyk
1Katedra Immunologii Klinicznej i Patologii, Collegium Medicum, Uniwersytet Jagielloński, Kraków. macuraa@poczta.wp.pl
Abstract:
The authors present a report of a seventeen year old girl with common variable immunodeficiency (CVID) and liver cirrhosis. A child of healthy, non-consanguineous parents was diagnosed at the age of 13 years to have immune deficiency and an early stage of liver cirrhosis. Patient revealed the following signs of immune deficiency: decreased level of serum immunoglobulins, considerably decreased number of B cells and CD4 cells and a lack of proliferative response to mitogen stimulation. The USG, scintigraphy and biopsy of liver confirmed the diagnosis of liver cirrhosis. The patient has been receiving intravenous immunoglobulins (IVIG) as substitutional treatment of CVID.
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