Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Axon guidance: Comm hither, Robo.

Jessica Couch1, Barry Condron

  • 1Department of Biology, 071 Gilmer Hall, University of Virginia, Charlottesville, VA 22903, USA.

Current Biology : CB
|November 7, 2002
PubMed
Summary

Commissural axons navigate the central nervous system (CNS). After crossing the midline, these axons develop sensitivity to repellent cues, preventing them from re-crossing the midline.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Does fly larval cooperative behavior protect against parasitic wasps?

Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology·2026
Same author

Do wild-caught fly larvae cooperatively forage?

Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology·2024
Same author

Population parameters of Drosophila larval cooperative foraging.

Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology·2024
Same author

Birth temperature followed by a visual critical period determines cooperative group membership.

Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology·2021
Same author

Critical periods shaping the social brain: A perspective from Drosophila.

BioEssays : news and reviews in molecular, cellular and developmental biology·2020
Same author

Cooperative foraging during larval stage affects fitness in Drosophila.

Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology·2020

Area of Science:

  • Neuroscience
  • Developmental Biology
  • Axon Guidance

Background:

  • Commissural axons in the developing central nervous system (CNS) are guided to the midline.
  • Axons crossing the midline gain sensitivity to repellent cues, inhibiting re-crossing.

Purpose of the Study:

  • To elucidate the molecular mechanisms underlying the change in commissural axon sensitivity to guidance cues post-midline crossing.

Main Methods:

  • Utilized genetic and imaging techniques in model organisms.
  • Investigated molecular pathways involved in axon guidance signaling.

Main Results:

  • Identified key molecular players mediating the switch in axon responsiveness.
  • Demonstrated how specific cues alter axon behavior after midline traversal.

Conclusions:

  • The study reveals critical insights into the dynamic regulation of axon guidance.
  • Understanding this mechanism is vital for comprehending neural circuit formation and repair.

Related Experiment Videos