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Anticancer activity for 4,4'-dihydroxybenzophenone-2,4-dinitrophenylhydrazone (A-007) analogues and their abilities
Lee Roy Morgan1, Branko S Jursic, Catherine L Hooper
1DEKK-TEC, Inc, New Orleans, LA 70119, USA.
Bioorganic & Medicinal Chemistry Letters
|November 7, 2002
Abstract:
The structure of the anticancer agent 4,4'-dihydroxybenzophenone-2,4-dinitrophenylhydrazone (A-007) has been modified through SAR and by incorporating barbituric acid, pyridine, quinoline, and alkylcarboxylic acids into A-007's moieties. Analogue anticancer activity and interacting with CD surface markers on a T-cell leukemia cell line were evaluated and the correlation between SAR and biological properties are discussed.