The problem of proton transfer in membranes
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Updated: Sep 28, 2026

Single Liposome Measurements for the Study of Proton-Pumping Membrane Enzymes Using Electrochemistry and Fluorescent Microscopy
Published on: February 21, 2019
1Inorganic Chemistry Laboratory, University of Oxford, South Parks Road, Oxford OX1 3QR, UK. bob.williams@chem.ox.ac.uk
Abstract:
Proton (H(+)) transfer has been examined in many molecular systems for more than 50 years. General mechanistic possibilities including tunnelling have been recognized for proton movement from local base-to-base centres. An especially fast mechanism over considerable distances, the Grotthus mechanism, has been described in water. Proton transfer over long distances in membranes which is now known to occur in many protein bio-energetic devices is not understood since ground state structures do not provide a continuous H-bond network. Here we consider the possible mechanisms and propose that the most likely pathway for protons in membranes uses an excited conformational state, equivalent to a partial denaturation.
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