[Functional state and reactivity of the adrenal cortex in rats with hereditarily conditioned hypertension]

Investigations conducted by the authors have made it certain that biosynthesis of cortico steroids from progesterone-C14 in rats of Ocamoto (SHR) line with hereditary-conditioned hypertension at chronic stage of the disease does not experience any substantial changes. At the same time, an acute emotional (immobilization) stress results in greater changes in the biosynthesis of corticosteroids, metabolism of aldosterone and its blood content in the SHR rats as compared to control, normotensive ones of the Wistar line. Hyperaldosteronism revealed in the SHR rats becomes particularly intensive in response to an additional neurogenic stimulation. An important role in the mechanism of its development plays reduced metabolism of aldosterone in the liver of the SHR rats, especially in response to a stress.