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A new method for evaluation of safety of antiarrhythmic drugs
V P Balashov1, L A Balykova, E N Shuvalova
1Department of Biology, Mordvinian State University. slava@mrsu.ru
Bulletin of Experimental Biology and Medicine
|November 7, 2002
Abstract:
A new method for preclinical evaluation of safety of antiarrhythmic drugs is proposed. During chronic stress, class I antiarrhythmic preparations increased mortality of test animals. By contrast, class II-IV antiarrhythmic agents and antioxidants produced no significant effect on mortality of experimental mice. These data agree with published results of multicenter studies.