Expression of Macrophage Colony-Stimulating Factor CSF-1 in Spinal Cord Neurons in Mice with Experimental Autoimmune
A V Balashov1, V P Balashov2, N P Shikhanov3
1Department of Cytology, Histology, and Embryology with Courses in Medical Biology and Molecular Biology of the Cell, N. P. Ogarev National Research Mordovia State University, Saransk, Republic of Mordovia, Russia. bvp63@yandex.ru.
Abstract:
In mice with acute and chronic models of experimental autoimmune encephalomyelitis (EAE), a quantitative study of the dynamics of CSF-1 and IL-34 protein levels in the spinal cord and blood plasma was conducted by ELISA and the specificity of CSF-1 expression in spinal cord cells was examined by immunohistological methods. A significant increase in the level of CSF-1 in the spinal cord was detected and populations of motoneurons with intense CSF-1 immunoreactivity were identified in mice with acute and chronic EAE. The obtained results suggest a possible role of CSF-1 in the pathogenesis and progression of EAE/multiple sclerosis.
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