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Use of Image Cytometry for Quantification of Pathogenic Fungi in Association with Host Cells
Published on: June 19, 2013
Immunohistochemical study of subcutaneous phaeohyphomycoses
C Romano1, C Miracco, L Presenti
1Institute of Dermatological Sciences, Siena University, Italy. mondelli@unisi.it
Mycoses
|November 8, 2002
Summary
This study analyzed inflammatory cells in subcutaneous phaeohyphomycosis before and after treatment. Fungal infections caused by Alternaria and Cladosporium showed changes in T cells and increased plasma cells post-therapy.
Area of Science:
- Medical Mycology
- Immunology
- Dermatology
Background:
- Subcutaneous phaeohyphomycosis is a fungal infection.
- Understanding the immune response is crucial for treatment.
Purpose of the Study:
- To investigate the immunohistochemical profile of inflammatory infiltrates in subcutaneous phaeohyphomycosis before and after therapy.
- To characterize the changes in T lymphocytes, plasma cells, and dendritic cells.
Main Methods:
- Immunohistochemical analysis of five subcutaneous phaeohyphomycosis cases.
- Evaluation of inflammatory cell populations (T cells, plasma cells, dendritic cells) pre- and post-therapy.
- Comparison with control skin samples.
Main Results:
- T helper memory cells increased, while suppressor cytotoxic T cells decreased post-therapy in most cases.
- Plasma cells (CD79a+) were abundant and slightly increased after therapy.
- Dendritic cells (CD1a+) showed high positivity in the epidermis and granulomatous infiltrate, with a slight decrease in the epidermis compared to controls.
Conclusions:
- Therapy for subcutaneous phaeohyphomycosis influences the T cell populations.
- Plasma cells and dendritic cells play a significant role in the inflammatory response to these fungal infections.
- Further research into the specific roles of these immune cells is warranted.
