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Novel syntheses of alpha-morpholinoamides from alpha,alpha-dichloroacetamides
Alan R Katritzky1, Yuming Zhang, Sandeep K Singh
1Center for Heterocyclic Compounds, Department of Chemistry, University of Florida, Gainesville, Florida 32611-7200, USA. katritzky@chem.ufl.edu
The Journal of Organic Chemistry
|November 9, 2002
Abstract:
Dichloroacetamides, on heating with benzotriazole, morpholine, and triethylamine, produce, in a one-pot reaction, alpha-benzotriazolyl-alpha-morpholinoacetamides 4a,b. Intermediates 4a and 4b react with nucleophiles such as allylsilanes, silyl ethers, and organozinc reagents to afford diverse alpha-morpholinoamides.