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Second-trimester amniocentesis vs. chorionic villus sampling for prenatal diagnosis in multiple gestations
A Antsaklis1, A P Souka, G Daskalakis
1First Department of Obstetrics and Gynecology, Alexandra Maternity Hospital, University of Athens, Athens, Greece.
Summary
First-trimester chorionic villus sampling (CVS) and second-trimester amniocentesis have similar fetal loss rates in multiple pregnancies. CVS is a safe alternative, especially when selective feticide is needed.
Area of Science:
- Maternal-Fetal Medicine
- Prenatal Diagnosis
- Reproductive Medicine
Background:
- Multiple pregnancies present unique challenges for prenatal diagnosis.
- Invasive procedures like chorionic villus sampling (CVS) and amniocentesis are used for genetic testing.
- Comparing the safety and efficacy of these procedures is crucial.
Purpose of the Study:
- To evaluate the impact of invasive prenatal diagnostic procedures on multiple pregnancies.
- To compare the outcomes of first-trimester chorionic villus sampling (CVS) with second-trimester amniocentesis.
Main Methods:
- A retrospective study involving 347 second-trimester amniocenteses and 69 first-trimester CVS procedures.
- Analysis of miscarriage rates, preterm delivery, and total fetal loss.
Main Results:
- Miscarriage rates were comparable: 4.18% for amniocentesis and 4.54% for CVS.
- Total fetal loss rates were similar: 8.8% for amniocentesis and 10.22% for CVS.
- In cases requiring selective feticide, CVS showed a trend towards lower fetal loss (8.3%) than amniocentesis (11.1%).
Conclusions:
- Chorionic villus sampling (CVS) is a safe alternative to amniocentesis for prenatal diagnosis in multiple pregnancies.
- CVS should be considered the preferred method, particularly in cases with a high risk of fetal abnormality requiring selective feticide.