Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Bornavirus and the brain.

Juan Carlos de la Torre1

  • 1Department of Neuropharmacology, Division of Virology, IMM-6, Scripps Research Institute, 10550 N. Torrey Pines Road, La Jolla, CA 92037, USA. juanct@scripps.edu

The Journal of Infectious Diseases
|November 9, 2002
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Clinical Characteristics, Risk Factors, and Predictors of Fatal Outcomes and Prolonged Hospitalization of Crimean-Congo Hemorrhagic Fever Cases in Basrah, Iraq.

Infectious disease reports·2026
Same author

Site-1 protease mediated GPC processing is required for persistence of LCMV Clone 13.

Npj viruses·2026
Same author

Prolyl tRNA Synthetase Is Required for Mammarenavirus Multiplication.

Viruses·2026
Same author

Prolyl tRNA Synthetase Is Required for Mammarenavirus Multiplication.

bioRxiv : the preprint server for biology·2026
Same author

Integrated phenotypic screening and chemical proteomics identifies ETF1 ligands that modulate viral translation and replication.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same author

Integrated phenotypic screening and chemical proteomics identifies ETF1 ligands that modulate viral translation and replication.

bioRxiv : the preprint server for biology·2025

Borna disease virus (BDV), a unique RNA virus, causes central nervous system disease and behavioral changes. Studying BDV in rats offers insights into human mental disorders and viral persistence.

Area of Science:

  • Virology
  • Neuroscience
  • Immunology

Background:

  • Borna disease virus (BDV) is a nonsegmented, negative-sense, single-stranded RNA virus.
  • BDV is the prototypic member of the Bornaviridae family, order Mononegavirales, known for unique genetic and biologic features.
  • BDV infection of the central nervous system (CNS) often results in behavioral abnormalities.

Purpose of the Study:

  • Investigate the molecular and cell biology of BDV to understand virus-cell interactions within the CNS.
  • Utilize BDV as a model system for studying viral persistence in the CNS.
  • Explore the potential of BDV as a model for human neuropsychiatric illnesses.

Main Methods:

  • Utilizing neonatal rat models of BDV infection.
  • Observing and analyzing neurodevelopmental, physiological, and neurobehavioral abnormalities in infected rats.

Related Experiment Videos

Main Results:

  • Neonatal BDV infection in rats leads to abnormalities mirroring features of human mental disorders.
  • BDV infection provides a model for studying viral persistence in the CNS.
  • Serologic and molecular epidemiologic studies suggest potential human BDV infection.

Conclusions:

  • BDV serves as a valuable model for understanding CNS viral diseases and their associated behavioral changes.
  • The study of BDV can offer new insights into virus-cell interactions in the brain.
  • BDV may provide a unique model for investigating the pathogenesis of human neuropsychiatric disorders.