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Application of Granger Causality Analysis of the Directed Functional Connection in Alzheimer's Disease and Mild Cognitive Impairment
08:43

Application of Granger Causality Analysis of the Directed Functional Connection in Alzheimer's Disease and Mild Cognitive Impairment

Published on: August 7, 2017

Alzheimer Disease: "It's okay, Mama, if you want to go, it's okay"

Ann C Hurley1, Ladislav Volicer

  • 1Center for Excellence in Nursing Practice, Brigham and Women's Hospital and School of Nursing, Bouve College of Health Sciences, Northeastern University, Boston, MA 02115, USA. Ahurley@partners.org

JAMA
|November 13, 2002
PubMed

Insights

Alzheimer disease (AD) affects millions, causing irreversible cognitive and functional decline. Physicians can guide patients and families through end-of-life care decisions during the terminal stages of this progressive neurological condition.

Area of Science:

  • Neurology
  • Geriatrics
  • Public Health

Background:

  • Alzheimer disease (AD) is a progressive neurological disorder affecting millions in the US.
  • The number of AD cases is projected to significantly increase in the coming decades.
  • AD presents complex challenges for patients, families, and healthcare providers.

Observation:

  • AD leads to irreversible cognitive and functional impairments.
  • Patients experience behavioral symptoms, personality changes, and loss of communication.
  • The disease duration can range from 2 to 20 years, culminating in life-threatening consequences.

Findings:

  • End-of-life care for AD patients involves difficult decisions regarding medical interventions and hospice.
  • Physicians play a crucial role in preparing patients and families for the disease's progression.
  • Support is vital for navigating the emotional and intellectual challenges at the end of life.

Implications:

  • Improved understanding of AD progression aids in proactive end-of-life planning.
  • Enhanced physician-patient communication can alleviate distress during terminal phases.
  • Healthcare systems need to support families facing complex care decisions for AD patients.
Keywords:
Death and EuthanasiaEmpirical ApproachProfessional Patient Relationship

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