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Proton MR spectroscopy of Wernicke encephalopathy
Mario Mascalchi1, Giacomo Belli, Laura Guerrini
1Department of Clinical Pathophysiology, Radiodiagnostica I, Università di Firenze, Firenze, Italy.
AJNR. American Journal of Neuroradiology
|November 13, 2002
Abstract:
Two patients with acute thiamine deficiency were examined with thalamic single-voxel proton MR spectroscopy. T2-weighted images exhibited increased signal intensity. N-acetylaspartate (NAA)/creatine (Cr) ratios were low without detectable lactate. Owing to substantially decreased choline (Cho) T2, the Cho/Cr ratio was not decreased. After thiamine therapy, the NAA/Cr ratio increased, paralleling clinical improvement and reduction in the areas of signal-intensity changes.