Controlled delivery of metoclopramide using an injectable semi-solid poly(ortho ester) for veterinary application

Area of Science:

• Biomaterials Science
• Veterinary Pharmacology
• Polymer Chemistry

Background:

• Current anti-emetic treatments for animal gastrointestinal disorders involve frequent oral or parenteral administration.
• Plasma concentration fluctuations from repeated dosing of anti-emetics can lead to severe side effects in animals.

Purpose of the Study:

• To develop a subcutaneous, biodegradable, controlled-release system for metoclopramide (MTC) in veterinary medicine.
• To improve therapeutic outcomes and reduce adverse effects associated with MTC treatment.

Main Methods:

• Synthesized semi-solid poly(ortho ester)s (POEs) via transesterification of trimethyl orthoacetate and 1,2,6,-hexanetriol.
• Formulated injectable POE matrices containing metoclopramide (MTC).
• Incorporated magnesium hydroxide (Mg(OH)2) into the POE formulation to modulate drug release.

Main Results:

• Low molecular weight POEs were successfully prepared for manual injection.
• MTC was rapidly released from the POE matrix via erosion and diffusion due to its properties.
• Incorporation of Mg(OH)2 extended the polymer lifetime and decreased the MTC release rate.
• The developed system demonstrated controlled release of MTC over several days.

Conclusions:

• A biodegradable, injectable poly(ortho ester) system containing metoclopramide was successfully developed for veterinary use.
• The addition of magnesium hydroxide effectively controlled the release rate of metoclopramide from the injectable formulation.
• This novel delivery system offers a promising alternative to frequent dosing regimens, potentially improving animal welfare and treatment efficacy.