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Tissue welding with biodegradable polymer films-demonstration of acute strength reinforcement in vivo
1Biomedical Engineering Program, University of Texas at Austin, Austin, Texas 78712, USA. brian.sorg@duke.edu
Background And Objectives:
To demonstrate, in vivo, acute strength reinforcement benefits of polymer film patches.
Study Design/Materials And Methods:
Full thickness incisions created in a dorsal skin flap of Sprague-Dawley rats were closed by laser-tissue welding: albumin solder was topically applied to the incision on the dermal surface, and a poly(lactic-co-glycolic acid) (PLGA) polymer film placed on the solder as a patch (controls had no film). Breaking strength was tested acutely (15-20 minutes after sacrifice).
Results:
The patched incisions were statistically stronger than the controls (ANOVA, P < 0.05).
Conclusions:
Polymer film patches may be a viable method to increase acute breaking strengths of welds using topically applied solder.
