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A practical approach to neutrophil disorders.

Wade Kyono1, Thomas D Coates

  • 1Division of Pediatric Hematology-Oncology, University of Hawaii John A. Burns School of Medicine, Kapiolani Medical Center, Honolulu 96826, USA. kyono@hawaii.edu

Pediatric Clinics of North America
|November 15, 2002
PubMed
Summary

This review covers neutrophil disorders, including neutropenia and neutrophilia, offering a framework for patient evaluation. It differentiates common conditions from rare, serious ones, focusing on clinically instructive neutrophil syndromes.

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Area of Science:

  • Hematology
  • Immunology
  • Clinical Medicine

Background:

  • Neutrophils play a critical role in innate immunity.
  • Disorders of neutrophil number (neutropenia, neutrophilia) and function can lead to increased susceptibility to infections.
  • Accurate diagnosis and management are essential for patient outcomes.

Purpose of the Study:

  • To provide a comprehensive review of neutrophil disorders.
  • To establish a framework for the clinical evaluation and management of patients with altered neutrophil counts or function.
  • To differentiate common, benign neutrophil syndromes from rare, severe disorders.

Main Methods:

  • Literature review of primary neutrophil disorders.
  • Discussion of diagnostic screening approaches.

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  • Focus on clinically common and instructive specific neutrophil syndromes.

    • Main Results:

    • Neutrophil disorders encompass quantitative (neutropenia, neutrophilia) and qualitative (dysfunction) abnormalities.
    • A systematic screening approach aids in distinguishing benign from serious conditions.
    • Specific primary neutrophil syndromes are detailed for better understanding.

    Conclusions:

    • Understanding neutrophil disorders is crucial for effective patient care.
    • A structured approach to evaluation and management improves diagnostic accuracy.
    • This review highlights key neutrophil syndromes for clinical relevance.