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Updated: Sep 28, 2026

Quantification of Metal Leaching in Immobilized Metal Affinity Chromatography
Published on: January 17, 2020
High-voltage contactless conductivity detection of metal ions in capillary electrophoresis
Jatisai Tanyanyiwa1, Peter C Hauser
1The University of Basel, Department of Chemistry, Basel, Switzerland.
Abstract:
The detection of alkali, alkaline earth and heavy metal ions with a high-voltage capacitively coupled contactless conductivity detector (HV-C(4)D) was investigated. Eight alkali, alkaline earth metal ions and ammonium could be separated in less than 4 min with detection limits in the order of 5 x 10(-8) M. The heavy metals Mn2+, Pb2+, Cd2+ Fe2+, Zn2+, Co2+, Cu2+ and Ni2+ could also be successfully resolved with a 10 mM 2-(N-morpholino)ethanesulfonic acid/DL-histidine (MES/His)-buffer. Zn2+, Co2+, Cu2+ and Ni2+ showed an indirect response. The detection limits for the heavy metals were determined to range from about 1 to 5 microM.
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