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Related Experiment Videos

Inherited dementias.

Peter Hedera1, R Scott Turner

  • 1Department of Neurology, Vanderbilt University, Nashville, Tennesse, USA.

Neurologic Clinics
|November 16, 2002
PubMed
Summary
This summary is machine-generated.

Familial dementia, a progressive cognitive decline, stems from various genetic disorders. This review focuses on prevalent causes like Alzheimer's disease, frontotemporal dementias, and prion diseases.

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Area of Science:

  • Neuroscience
  • Genetics
  • Neurology

Background:

  • Dementia is a progressive cognitive decline associated with numerous genetic disorders.
  • The Online Mendelian Inheritance in Man database lists 162 entries for dementia, highlighting its genetic complexity.
  • Familial dementias often present initially with primary cognitive impairment.

Purpose of the Study:

  • To review prevalent and illustrative etiologies of familial dementia in adults.
  • To focus on genetic disorders with an initial and primarily dementing clinical presentation.

Main Methods:

  • Literature review of genetic causes of dementia.
  • Focus on specific familial dementia syndromes.

Main Results:

Related Experiment Videos

  • Familial Alzheimer's disease (AD) and related amyloid angiopathies.
  • Frontotemporal dementias (FTD) and related tauopathies.
  • Familial prion diseases, British and Danish familial dementias, and CADASIL.

Conclusions:

  • Genetic factors play a significant role in various forms of dementia.
  • Understanding these specific familial dementias is crucial for diagnosis and research.