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Updated: Sep 28, 2026

Application of the Intelligent High-Throughput Antimicrobial Sensitivity Testing/Phage Screening System and Lar Index of Antimicrobial Resistance
09:59

Application of the Intelligent High-Throughput Antimicrobial Sensitivity Testing/Phage Screening System and Lar Index of Antimicrobial Resistance

Published on: July 21, 2023

[Surveillance for antimicrobial resistance: VIRA Study]

Juan J Picazo1, Carmen Betriu, Iciar Rodríguez-Avial

  • 1Servicio de Microbiología Clínica. Hospital Clínico San Carlos. Madrid. España.

Enfermedades Infecciosas Y Microbiologia Clinica
|November 16, 2002
PubMed
Abstract

Insights

Antimicrobial resistance is rising in Spain, with significant rates of ciprofloxacin-resistant E. coli and methicillin-resistant Staphylococcus aureus (MRSA). This highlights the urgent need for ongoing surveillance programs to combat multi-drug resistant organisms.

Area of Science:

  • Medical Microbiology
  • Infectious Diseases
  • Pharmacology

Background:

  • Antimicrobial drug resistance is a growing global health concern.
  • Recent years have seen an increase in drug-resistant infections.

Purpose of the Study:

  • To assess the current antimicrobial resistance patterns in Spain.
  • To identify the prevalence of resistance in common infectious agents.

Main Methods:

  • A multicenter study involving 38 hospitals in Spain.
  • Analysis of 1,475 microbial strains, including MRSA, CNS, E. coli, S. pneumoniae, and A. baumannii.
  • Broth microdilution method for antibiotic sensitivity testing.

Main Results:

  • 24% incidence of ciprofloxacin-resistant E. coli and MRSA.
  • Penicillin-resistant Streptococcus pneumoniae showed resistance to multiple antibiotics.
  • Telithromycin demonstrated high efficacy against resistant pneumococci.
  • All staphylococci were susceptible to linezolid and quinupristin-dalfopristin.

Conclusions:

  • Evidence of increasing multi-drug resistance in key pathogens like MRSA and E. coli.
  • The study underscores the critical need for robust surveillance programs.
  • Monitoring resistance patterns is essential for addressing this therapeutic challenge.

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