Related Experiment Video
Updated: Jul 9, 2026

In Vitro Differentiation of Human Pluripotent Stem Cells into Trophoblastic Cells
Published on: March 16, 2017
On the origin of interictal activity in human temporal lobe epilepsy in vitro
Ivan Cohen1, Vincent Navarro, Stéphane Clemenceau
1EMI 0224, CHU Pitié-Salpêtrière, Université Paris VI, 75013 Paris, France.
Abstract:
The origin and mechanisms of human interictal epileptic discharges remain unclear. Here, we describe a spontaneous, rhythmic activity initiated in the subiculum of slices from patients with temporal lobe epilepsy. Synchronous events were similar to interictal discharges of patient electroencephalograms. They were suppressed by antagonists of either glutamatergic or gamma-aminobutyric acid (GABA)-ergic signaling. The network of neurons discharging during population events comprises both subicular interneurons and a subgroup of pyramidal cells. In these pyramidal cells, GABAergic synaptic events reversed at depolarized potentials. Depolarizing GABAergic responses in neurons downstream to the sclerotic CA1 region contribute to human interictal activity.
Related Concept Videos
In-vitro Mutagenesis
In vitro Mutagenesis
Cell Culture
In Vitro Fertilization
The IVF process begins with ovarian stimulation, during which reproductive endocrinologists prescribe hormonal medications to stimulate the ovaries to produce multiple eggs instead of the single...

