Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Idiopathic cardiomyopathies].

Michel Komajda1, Philippe Charron

  • 1Département de cardiologie Centre hospitalier universitaire La Pitié-La Salpêtrière 75651 Paris. michel.komajda@psl.ap-hop-paris.fr

La Revue Du Praticien
|November 19, 2002
PubMed
Summary

Heart muscle diseases like dilated and hypertrophic cardiomyopathy cause significant morbidity and mortality. Genetic research is uncovering their pathophysiology, paving the way for new treatments.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Cardiac and extracardiac outcomes after heart transplantation in laminopathies.

Heart (British Cardiac Society)·2026
Same author

Use of Disopyramide in Obstructive Hypertrophic Cardiomyopathy: A European Insight.

Journal of clinical medicine·2026
Same author

Optimal serum potassium concentrations in heart failure: an individual patient data meta-analysis.

European heart journal·2026
Same author

Sudden cardiac death and major arrhythmic events in patients with Fabry disease: Risk stratification in the French Heart Fabry cohort multicenter study.

Heart rhythm·2026
Same author

Two novel real-time PCR assays for <i>Brucella</i> detection: a species-specific multiplex and a genus-level singleplex developed via large-scale whole genome sequencing data analysis.

Microbiology spectrum·2026
Same author

Genetic counselling implementation in dilated cardiomyopathy.

European heart journal·2026

Area of Science:

  • Cardiology
  • Genetics
  • Pathophysiology

Context:

  • Heart muscle diseases, including dilated and hypertrophic cardiomyopathy, present a significant health burden.
  • These conditions are linked to systolic or diastolic dysfunction, leading to heart failure or sudden death.
  • Dilated cardiomyopathy is a leading cause for heart transplantation, while hypertrophic cardiomyopathy is a primary cause of sudden death in athletes.

Purpose:

  • To investigate the pathophysiology of heart muscle diseases using molecular genetics.
  • To highlight the importance of familial screening for monogenic forms of these diseases.
  • To explore the development of novel therapeutic strategies based on new genetic insights.

Summary:

  • Heart muscle diseases are prevalent and morbid, often progressing to heart failure or sudden death.
  • Dilated cardiomyopathy and hypertrophic cardiomyopathy are leading causes for transplantation and sudden death in athletes, respectively.
  • Molecular genetics is advancing the understanding of previously idiopathic cardiomyopathies, revealing frequent familial and monogenic forms.

Impact:

  • Advances in understanding the genetic basis of cardiomyopathies.
  • Potential for developing targeted therapies for heart muscle diseases.
  • Improved diagnostic and screening protocols for at-risk family members.

Related Experiment Videos