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Updated: Sep 28, 2026
An In Vivo Estrogen Deficiency Mouse Model for Screening Exogenous Estrogen Treatments of Cardiovascular Dysfunction After Menopause
Published on: August 13, 2019
[Effect of hormone replacement therapy on the cardiovascular system]
Insights
Hormone replacement therapy (HRT) impacts cardiovascular health by favorably altering lipid profiles, such as decreasing LDL-C and increasing HDL-C. However, certain HRT formulations may increase cardiovascular risk, necessitating careful patient selection.
Area of Science:
- Endocrinology
- Cardiovascular Medicine
- Gynecology
Context:
- Hormone replacement therapy (HRT) is widely used for managing menopausal symptoms.
- Its influence on the cardiovascular system is complex and debated.
- Understanding these effects is crucial for patient safety and therapeutic efficacy.
Purpose:
- To analyze current knowledge on the cardiovascular effects of hormone replacement therapy (HRT).
- To review how different HRT formulations impact cardiovascular risk factors.
- To synthesize findings on lipid profiles, body fat distribution, and vascular function.
Summary:
- Oral estrogens decrease LDL-C and increase HDL-C, while transdermal estradiol has milder lipid effects.
- Progestins can counteract beneficial estrogen effects on HDL-C, depending on their type (androgenic vs. non-androgenic).
- HRT may improve body fat distribution and vascular function, but oral estrogen therapy can increase CRP, potentially raising cardiovascular risk initially.
Impact:
- Provides a comprehensive overview of HRT's cardiovascular effects, aiding clinical decision-making.
- Highlights the importance of formulation choice and patient history in HRT prescription.
- Informs strategies for mitigating potential cardiovascular risks associated with HRT.
Objective:
Analysis of contemporary knowledge of influences of hormone replacement therapy on cardiovascular system.
Design:
Literary review.
Setting:
Department of Gynecology and Obstetrics, 1st Faculty of Medicine, Charles University, Prague.
Method:
Informations were collected from full-texts which were chosen in database Medline and Ovid.
Conclusion:
Hormone replacement therapy (HRT) has positive influence on some risk factors of cardiovascular disease. Changes in the lipoprotein spectrum are well known. Oral estrogens cause a decrease of low density lipoprotein cholesterol (LDL-C) and, especially an increase of high density lipoprotein cholesterol (HDL-C) levels, which both have potentially favourable effects; they also cause a triglyceride level increase, which probably has no clinical relevance except in cases with basal hypertriglyceridemia. Transdermal estradiol causes generally a minor decrease in LDL-C and minor increase HDL-C levels, with no increase or even decrease in triglyceride levels. The addition of androgenic progestins at conventionally used doses, while not interfering with LDL-C variations, causes a HDL-C decrease, which contrasts he effect of oral estrogens and completely reverses the effect of transdermal estradiol. On the contrary, the addition of a non-adrogenic progestin does not interfere with any of the estrogen induced lipid profile modifications. Transdermal estradiol does not cause change of insulinoresistance. Estrogen substitution protects gynoid distribution of body fat that is connected with lower risk of ischemic heart disease. Estrogens have possibility to dilate vessels. Decreasing of levels of cytoadhesive molecules was verify during HRT so as lowering of homocysteine level to premenopausal levels. Newly uncovered changes like the significant increase of CRP connected with oral estrogen therapy could explain increasing of cardiovascular risk on the beginning of HRT especially in group of women with history of ischemic heart disease.
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