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Related Experiment Videos

Does gender difference influence outcome?

Martin A Croce1, Timothy C Fabian, Ajai K Malhotra

  • 1Department of Surgery, University of Tennessee Health Science Center, Memphis 38163, USA. mcroce@utmem.edu

The Journal of Trauma
|November 19, 2002
PubMed
Summary
This summary is machine-generated.

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Gender did not impact overall trauma patient mortality, though women experienced higher mortality from pneumonia. Further research is needed before considering hormonal interventions for trauma patients.

Area of Science:

  • Trauma research
  • Immunology
  • Gender-based medicine

Background:

  • Emerging evidence suggests immune response variations between sexes in rodents and humans, particularly in sepsis.
  • Hormonal influences (testosterone and estrogen) are implicated in these gender-based differences.
  • Clinical trials investigating hormonal manipulation for males have been proposed.

Purpose of the Study:

  • To investigate the influence of gender on diverse outcomes in trauma patients.
  • To analyze trauma patient data for gender-specific differences in mortality and morbidity.
  • To inform potential future therapeutic strategies targeting hormonal pathways.

Main Methods:

  • Retrospective analysis of trauma registry data over 52 months, excluding early deaths.

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  • Outcomes assessed included mortality, pneumonia, acute respiratory distress syndrome, bacteremia, and resource utilization (ventilator and ICU/hospital days).
  • Patients were stratified by injury mechanism, gender, age (premenopausal/postmenopausal for women), and injury severity.

    • Main Results:

    • A total of 18,133 patients were identified (73% male, 27% female).
    • No significant gender or age-related outcome differences were observed after penetrating trauma.
    • While men had more infections, women showed lower survival rates when infected; logistic regression found no independent effect of gender on mortality.

    Conclusions:

    • No overall mortality difference was found between genders in trauma patients.
    • Women with pneumonia exhibited a higher mortality rate compared to men.
    • Further investigation into underlying mechanisms is required prior to exploring hormonal manipulation in trauma care.