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Updated: Aug 8, 2026
From a 2DE-Gel Spot to Protein Function: Lesson Learned From HS1 in Chronic Lymphocytic Leukemia
Published on: October 19, 2014
High occurence of DRB1 11 in chronic lymphocytic leukaemia families
Ioannis Theodorou1, Laurent Abel, Francesca Mauro
1Laboratoire Central d' Immunologie Cellulaire Hôpital Pitié Salpêtrière, INSERM U550 Génétique Humaine des Maladies Infectieuses, Hôpital Necker-Enfants Malades, Paris, France. itheodor@infobiogen.fr
Abstract:
Recently, linkage analysis of a series of familial chronic lymphocytic leukaemia (CLL) showed that affected sibling pairs did not share common major histocompatibilty complex haplotypes. We analysed Class I and II antigens in 11 Italian families with familial CLL. Although there was no association of disease status with any particular human leucocyte antigen, there was an overrepresentation of DRB1 11 alleles in these families (P = 0.009). A similar trend was also observed in a second series of nine French families (P = 0.002). Larger studies are needed to determine whether non-inherited paternal or maternal DRB1 antigens play a role in familial CLL development.
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