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Methods for the Modulation and Analysis of NF-κB-dependent Adult Neurogenesis
Published on: February 13, 2014
Proteolytic processing of chromogranins is modified in brains of transgenic mice
Andrea Laslop1, Alexandra Becker, Iris Lindberg
1Department of Pharmacology, University of Innsbruck, A-6020 Innsbruck, Austria. andrea.laslop@uibk.ac.at
Annals of the New York Academy of Sciences
|November 20, 2002
Abstract:
In normal brain, secretogranin II and chromogranins A and S are extensively converted by endopeptidases to the peptides secretoneurin, GE-19, and PE-11, respectively. After genetic knockout of PC2 or its helper protein 7B2, but not after mutation of carboxypeptidase E, endoproteolytic processing decreased, as indicated by appearance of intermediate-sized processing products.
