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Apathy in Parkinson's disease.

G C Pluck1, R G Brown

  • 1Division of Psychological Medicine, Section of Old Age Psychiatry, Institute of Psychiatry, King's College London, London SE5, UK. g.pluck@iop.kcl.ac.uk

Journal of Neurology, Neurosurgery, and Psychiatry
|November 20, 2002
PubMed
Summary

Apathy is common in Parkinson's disease and linked to cognitive decline, not disability or mood. This suggests physiological changes, not psychological adaptation, cause apathy in Parkinson's patients.

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Area of Science:

  • Neurology
  • Neuropsychiatry

Background:

  • Apathy is a frequent symptom in Parkinson's disease (PD).
  • The underlying causes of apathy in PD, whether disease-related or psychological, require further investigation.

Purpose of the Study:

  • To evaluate apathy levels in Parkinson's disease patients.
  • To explore the relationship between apathy and disability, mood, personality, and cognitive function in PD.

Main Methods:

  • Compared apathy in 45 PD patients to 17 osteoarthritis patients matched for disability.
  • Assessed depression, anxiety, hedonic tone, personality, and cognitive functions including executive functioning.

Main Results:

  • PD patients exhibited significantly higher apathy than osteoarthritis patients.
  • Apathy in PD was not correlated with disease progression, depression, or anxiety, but with reduced hedonic tone.
  • High-apathy PD patients showed poorer performance on cognitive tests, especially executive functions, compared to low-apathy PD patients.

Conclusions:

  • Apathy in Parkinson's disease appears to stem from physiological changes rather than psychological adaptation to disability.
  • Apathy is distinct from other psychiatric symptoms in PD and is closely linked to cognitive impairment, particularly executive dysfunction.
  • Cognitive mechanisms may play a significant role in the manifestation of apathy in Parkinson's disease.

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