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DNA Microarrays: Sample Quality Control, Array Hybridization and Scanning
Published on: March 15, 2011
Streamlining microarray technology in a prototype core laboratory
Brian Soriano1, Pamela Bean, Jeanette Gaydos
1University of Colorado Health Sciences Center (UCHSC), 4200 E. Ninth Ave., Box C-236, Denver, CO 80262, USA. brian.soriano@uchsc.edu
American Clinical Laboratory
|November 21, 2002
Summary
Microarrays generate valuable gene expression data for research. This core laboratory provides custom cDNA arrays for studying gene interactions in cancer and neuroscience, supporting genomic discovery.
Area of Science:
- Genomics
- Molecular Biology
- Bioinformatics
Background:
- Microarrays offer a powerful platform for high-throughput gene expression analysis.
- Access to specialized arrays accelerates research in various biological fields.
Purpose of the Study:
- To describe the capabilities and applications of a core laboratory producing custom cDNA microarrays.
- To highlight the utility of these arrays in advancing cancer and neuroscience research.
Main Methods:
- Development and utilization of three cDNA arrays: a mouse 15K array, a human 13K array, and a human apoptosis array.
- Application of arrays for building gene expression databases and studying gene interactions.
Main Results:
- The mouse 15K array is utilized for gene expression profiling in the mouse brain and in transgenic/knockout models.
- The human apoptosis array aids cancer researchers in elucidating gene networks involved in cell death and oncogenesis.
Conclusions:
- The Gene Expression Array Core provides essential genomic tools for academic researchers.
- These resources facilitate research in alcohol-related cancers and other complex diseases.
