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Streamlining microarray technology in a prototype core laboratory.

Brian Soriano¹, Pamela Bean, Jeanette Gaydos

¹University of Colorado Health Sciences Center (UCHSC), 4200 E. Ninth Ave., Box C-236, Denver, CO 80262, USA. brian.soriano@uchsc.edu

American Clinical Laboratory

|November 21, 2002

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Microarrays generate valuable gene expression data for research. This core laboratory provides custom cDNA arrays for studying gene interactions in cancer and neuroscience, supporting genomic discovery.

Area of Science:

Genomics
Molecular Biology
Bioinformatics

Background:

Microarrays offer a powerful platform for high-throughput gene expression analysis.
Access to specialized arrays accelerates research in various biological fields.

Purpose of the Study:

To describe the capabilities and applications of a core laboratory producing custom cDNA microarrays.
To highlight the utility of these arrays in advancing cancer and neuroscience research.

Main Methods:

Development and utilization of three cDNA arrays: a mouse 15K array, a human 13K array, and a human apoptosis array.
Application of arrays for building gene expression databases and studying gene interactions.

Main Results:

The mouse 15K array is utilized for gene expression profiling in the mouse brain and in transgenic/knockout models.

Related Experiment Videos

The human apoptosis array aids cancer researchers in elucidating gene networks involved in cell death and oncogenesis.

Conclusions:

The Gene Expression Array Core provides essential genomic tools for academic researchers.
These resources facilitate research in alcohol-related cancers and other complex diseases.