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Low temperature crystal structure of natural diosgenone
Oscar E Piro1, Eduardo E Castellano, Gloria E Tobón Zapata
1Departamento di Física and Instituto IFLP (CONICET), Facultad de Ciencias Exactas, Universidad Nacional de La Plata, Argentina.
Zeitschrift Fur Naturforschung. C, Journal of Biosciences
|November 21, 2002
Summary
The molecular structure of diosgenone, a steroidal sapogenin from Solanum nudum, was determined using X-ray crystallography. This study provides the first structural report for a diosgenin-group sapogenin.
Area of Science:
- Natural Product Chemistry
- Crystallography
- Organic Chemistry
Background:
- Diosgenone is a natural steroidal sapogenin.
- It is closely related to diosgenin.
- Diosgenone was isolated from Solanum nudum.
Purpose of the Study:
- To determine the molecular structure of diosgenone.
- To provide the first structural report for a steroidal sapogenin from the diosgenin group.
Main Methods:
- Single crystal X-ray diffractometry at 120 K.
- Full-matrix least-squares refinement.
- Crystallographic analysis in the monoclinic space group P2(1).
Main Results:
- The molecular structure of diosgenone was solved.
- The crystal structure was refined to an agreement factor R1 = 0.054.
- Unit cell parameters: a = 15.1870(4) Å, b = 7.2710(2) Å, c = 21.2840(6) Å, β = 99.251(1)°.
- Four molecules were present in the unit cell (Z = 4).
Conclusions:
- The study successfully elucidated the molecular structure of diosgenone.
- This work represents the first structural characterization of a diosgenin-group steroidal sapogenin.
- The findings contribute to the understanding of steroidal sapogenin structures.