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Updated: Aug 16, 2026

Biosensor-based High Throughput Biopanning and Bioinformatics Analysis Strategy for the Global Validation of Drug-protein Interactions
Published on: December 1, 2020
New paradigm of q-CAR drug development targeting disease-specific protein conformations
Libin Ye1,2,3
1Department of Molecular Biosciences, University of South Florida, Tampa, FL, USA. libinye@usf.edu.
Abstract:
Drug discovery has progressed to using advanced AI-driven platforms. These systems rely heavily on static structures and overlook an essential aspect: protein motion-conformational transitions and local fluctuations-is essential for function, as "no motion, no function." Thus, this review discusses recent progress in measuring protein conformations and dynamics and introduces a new concept, "quantitative conformation-activity relationship (q-CAR)," aimed at developing drugs that target disease-specific protein conformations in the future.
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