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Synthesis and antimitotic activity of novel 2-methoxyestradiol analogs
Pemmaraju N Rao1, James W Cessac, Tina L Tinley
1Department of Organic Chemistry, Southwest Foundation for Biomedical Research, P O Box 760549, San Antonio, TX 78245-0549, USA. pnrao@icarus.sfbr.org
Steroids
|November 21, 2002
Abstract:
The syntheses and antimitotic activity of several novel 2-methoxyestradiol analogs are described. Structural modifications investigated include introduction of additional unsaturation in rings B and D; inversion at C-13; and substitution at the C-2, C-15, C-16, and C-7 alpha positions. Of 15 analogs synthesized, 2 have demonstrated superior biological activities compared to 2-methoxyestradiol.