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Bioactive 4-substituted-6-methyl-2-pyrones with promising cytotoxicity against A2780 and K562 cell lines
Lester R Marrison1, Julia M Dickinson, Ian J S Fairlamb
1Department of Chemistry and Materials, John Dalton Building, The Manchester Metropolitan University, Chester Street, UK.
Bioorganic & Medicinal Chemistry Letters
|November 22, 2002
Abstract:
Bioactive synthetic 4-substituted-6-methyl-2-pyrones are reported. Various 4-substitutents have been incorporated using Pd-catalysed carbon-carbon bond coupling procedures. Preliminary screening of the 2-pyrones against human ovarian carcinoma (A2780) and human chronic myelogenous leukaemia (K562) cell lines show that 4-alkynyl-6-methyl-2-pyrones have excellent potential as anticancer agents. The pyrones demonstrate broad spectrum antimicrobial activities.