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Related Experiment Videos

Slaving: solvent fluctuations dominate protein dynamics and functions.

P W Fenimore1, H Frauenfelder, B H McMahon

  • 1Center for Nonlinear Studies, MS B258, and Theoretical Biophysics Group, MS K-710, Los Alamos National Laboratory, Los Alamos, NM 87545, USA.

Proceedings of the National Academy of Sciences of the United States of America
|November 22, 2002
PubMed
Summary

Protein motions are either independent (nonslaved) or coupled (slaved) to solvent fluctuations. Slaved protein dynamics, crucial for cellular function, are influenced by the surrounding environment and hydration shell.

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Area of Science:

  • Biophysics
  • Biochemistry
  • Molecular Biology

Background:

  • Protein dynamics are critical for biological function.
  • Solvent dielectric fluctuations influence protein processes.
  • Protein motions can be categorized based on their coupling to solvent dynamics.

Purpose of the Study:

  • To classify protein motions based on their relationship with solvent dielectric fluctuations.
  • To elucidate the roles of protein conformation, solvent, and hydration shell in protein dynamics.
  • To differentiate between nonslaved and slaved protein processes.

Main Methods:

  • Comparison of protein process rates with solvent dielectric fluctuation rates.
  • Analysis of temperature dependence to determine activation enthalpy and entropy.

Related Experiment Videos

  • Identification of distinct classes of protein motions: nonslaved and slaved.

    • Main Results:

    • Protein motions are divided into two classes: nonslaved and slaved.
    • Nonslaved processes (e.g., bond formation) are independent of solvent motions.
    • Slaved processes (e.g., channel gating) are coupled to solvent fluctuations, sharing similar temperature dependence.
    • Solvent influences activation enthalpy, while protein and hydration shell control activation entropy.

    Conclusions:

    • Slaved motions are prevalent, emphasizing the environment's role in protein function within cells and membranes.
    • Understanding the interplay between protein dynamics and solvent is key to deciphering biological mechanisms.
    • The proposed model distinguishes protein motion types and their environmental dependencies.