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Catalytic Leuckart-Wallach-type reductive amination of ketones
Masato Kitamura1, Donghyun Lee, Shinnosuke Hayashi
1Research Center for Materials Science and the Department of Chemistry, Nagoya University, Chikusa, Nagoya 464-8602, Japan.
The Journal of Organic Chemistry
|November 26, 2002
Abstract:
A CpRh(III) complex catalyzes reductive amination of ketones using HCOONH(4) at 50-70 degrees C to give the corresponding primary amines in high yields. The reaction is clean and operationally simple and proceeds at a lower temperature and with higher chemoselectivity than the original Leuckart-Wallach reaction. The new method has been applied to the synthesis of alpha-amino acids directly from alpha-keto acids.