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Microbial metabolism of artemisinin by Mucor polymorphosporus and Aspergillus niger
Ji-Xun Zhan1, Yuan-Xing Zhang, Hong-Zhu Guo
1The State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing 100083, People's Republic of China.
Journal of Natural Products
|November 26, 2002
Abstract:
Artemisinin (1) was transformed by Mucor polymorphosporus and Aspergillus niger. Five products were identified as 9beta-hydroxyartemisinin (2), 3beta-hydroxyartemisinin (3), deoxyartemisinin (4), 3beta-hydroxydeoxyartemisinin (5), and 1alpha-hydroxydeoxyartemisinin (6). Products 2, 3, and 6 are new compounds.