Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Calreticulin in cardiac development and pathology.

Marek Michalak1, Jeffrey Lynch, Jody Groenendyk

  • 1Canadian Institutes of Health Research Membrane Protein Research Group and Department of Biochemistry, University of Alberta, Edmonton, Alberta, Canada.

Biochimica Et Biophysica Acta
|November 26, 2002
PubMed
Summary

Calreticulin, an endoplasmic reticulum (ER) chaperone, is crucial for cardiac development. Its deficiency or overexpression in mice leads to severe cardiac abnormalities, highlighting its role in heart function.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Localized phosphoinositide metabolism regulates STIM1/ORAI1 fast inactivation.

iScience·2026
Same author

Myotubularin related protein 7, a novel STIM1 binding protein.

Canadian journal of physiology and pharmacology·2025
Same author

Sex estimation from humeral and femoral head diameters using CT-scans of living Finns.

Legal medicine (Tokyo, Japan)·2024
Same author

Selective regulation of aspartyl intramembrane protease activity by calnexin.

Cellular and molecular life sciences : CMLS·2024
Same author

Interplay between myotubularins and Ca<sup>2+</sup> homeostasis.

Biochimica et biophysica acta. Molecular cell research·2024
Same author

Interplay between calcium and endoplasmic reticulum stress.

Cell calcium·2023

Area of Science:

  • Molecular Biology
  • Cardiovascular Biology
  • Cell Biology

Background:

  • Calreticulin is a calcium-binding chaperone in the endoplasmic reticulum (ER).
  • It plays a vital role in the calreticulin/calnexin cycle and ER quality control.
  • Calreticulin is highly expressed during early cardiac development.

Purpose of the Study:

  • To investigate the role of calreticulin in cardiac development and function.
  • To explore the impact of calreticulin deficiency and overexpression on the heart.
  • To elucidate calreticulin's regulatory role in calcineurin-dependent pathways.

Main Methods:

  • Studies utilized calreticulin-deficient and transgenic mouse models.
  • Cardiac development and function were assessed in these models.

Related Experiment Videos

  • Molecular pathways, including calcineurin signaling, were analyzed.

    • Main Results:

    • Calreticulin deficiency in mice resulted in lethal cardiac developmental defects.
    • Overexpression of calreticulin led to bradycardia, heart block, and sudden death.
    • Calreticulin was identified as a key regulator of calcineurin pathways in cardiac development.

    Conclusions:

    • Calreticulin is essential for normal cardiac development and function.
    • Dysregulation of calreticulin impacts cardiac pathologies.
    • The endoplasmic reticulum and calreticulin are critical for heart development and postnatal health.