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An In Vivo Estrogen Deficiency Mouse Model for Screening Exogenous Estrogen Treatments of Cardiovascular Dysfunction After Menopause
Published on: August 13, 2019
Use of alternative and complementary medicine in menopause
H J Kang1, R Ansbacher, M M Hammoud
1Division of Reproduction Endocrinology and Infertility, Department of Obstetrics and Gynecology, University of Michigan Medical School, Ann Arbor, MI, USA.
Alternative therapies like soy isoflavones may offer slight cholesterol reduction and ipriflavone may improve bone density in menopause. However, more research is needed to confirm benefits for menopausal symptoms.
Area of Science:
- Integrative Medicine
- Women's Health
- Menopause Management
Background:
- Menopausal symptoms significantly impact women's quality of life.
- Alternative and complementary medicine (ACM) is frequently explored for symptom relief.
Purpose of the Study:
- To review existing clinical evidence on ACM for menopausal symptom treatment.
- Evaluate ACM efficacy for vasomotor symptoms, lipid profiles, and bone mineral density.
Main Methods:
- Systematic review of MEDLINE, PREMEDLINE, and COCHRANE databases (1980-2002).
- Included studies on soy products, black cohosh, dong quai, acupuncture, ginseng, and evening primrose oil.
- Focused on clinical trials examining menopausal vasomotor symptoms, lipid profiles, and bone mineral density.
Main Results:
- Soy isoflavones showed a modest decrease in total and LDL cholesterol, with uncertain clinical significance.
- Ipriflavone, a synthetic isoflavone, increased bone mineral density in peri- and postmenopausal women.
- Current data do not support soy's efficacy for vasomotor symptoms; evidence for other ACMs is insufficient.
Conclusions:
- ACM may have a role in menopause management.
- Well-designed, large-scale studies are essential to validate the efficacy and safety of ACMs for menopausal symptoms.
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