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Updated: Aug 9, 2026
A Simple Approach to Induce Experimental Autoimmune Neuritis in C57BL/6 Mice for Functional and Neuropathological Assessments
Published on: November 9, 2017
Efficacy of leukemia inhibitory factor in experimental autoimmune neuritis
M Laurà1, N A Gregson, Y Curmi
1Department of Neurological Sciences, Psychiatry and Anaesthesiology, University of Messina, 98125, Messina, Italy. matilde.laura@tin.it
Abstract:
Leukemia inhibitory factor (LIF) is a pleiotropic cytokine that exerts neurotrophic and myotrophic actions. We have investigated the effect of LIF in experimental autoimmune neuritis (EAN), an animal model of Guillain-Barré syndrome (GBS). Treatment with LIF at the onset of the disease showed a slight, but not significant, improvement in the clinical course but no effect on nerve histology.
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