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A tender sinus does not always mean rhinosinusitis.

K Naranch1, Y-J Park, M S Repka-Ramirez

  • 1Chronic Pain and Fatigue Research Center, Division of Rheumatology, Immunology and Allergy, Georgetown University, Washington, DC 20007-2097, USA.

Otolaryngology--Head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery
|November 26, 2002
PubMed
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Quantitative assessment of sinus tenderness revealed significant differences across various conditions. Chronic fatigue syndrome (CFS) patients exhibited lower sinus and systemic tenderness thresholds, suggesting hyperalgesia contributes to their symptoms.

Area of Science:

  • Medical research
  • Pain assessment
  • Neurology

Background:

  • Sinus tenderness, a common symptom, has lacked quantitative evaluation.
  • Understanding pain thresholds in sinus-related conditions is crucial for diagnosis and treatment.

Purpose of the Study:

  • To quantitatively compare sinus and systemic tenderness thresholds.
  • To differentiate tenderness levels in rhinosinusitis, allergic rhinitis, and chronic fatigue syndrome (CFS) compared to healthy individuals.

Main Methods:

  • Measured cutaneous pressure thresholds (kg/cm(2)) at 5 sinus and 18 systemic sites.
  • Included participants with acute/chronic rhinosinusitis, allergic rhinitis, CFS, and healthy controls (non-CFS).

Main Results:

Related Experiment Videos

  • Significant differences in sinus pressure thresholds were observed across all groups (P <= 10(-11)).
  • CFS groups (with or without rhinosinusitis) showed lower sinus thresholds (0.98-0.78 kg/cm(2)) compared to non-CFS groups (1.59-1.10 kg/cm(2)).
  • Systemic pressure thresholds were significantly lower in CFS (1.46 kg/cm(2)) than in non-CFS subjects (2.67 kg/cm(2)).

    • Conclusions:

    • Lower sinus thresholds validate sinus tenderness as a clinical sign in rhinosinusitis.
    • CFS patients exhibit both reduced sinus and systemic pain thresholds, indicating systemic hyperalgesia.
    • Systemic hyperalgesia likely contributes to sinus tenderness and perceived "rhinosinusitis" symptoms in CFS patients.